32 NEET previous-year questions on Chemical Coordination and Integration, each with the correct answer and a step-by-step solution. Sourced directly from official NEET papers across every booklet code.
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Oxytocin-posterior pituitary, growth and maintenance of mammary glands.
Melatonin-pineal gland, regulates the normal rhythm of sleep-wake cycle
Progesterone-corpus-luteum, stimulation of growth and activities of female secondary sex organs.
Atrial natriuretic factor-ventricular wall increases the blood pressure.
Solution
Melatonin is secreted by the pineal gland and regulates the sleep-wake cycle, so option (b) is correct. Oxytocin is involved in milk ejection and uterine contractions, progesterone is involved in maintaining pregnancy, and atrial natriuretic factor decreases blood pressure by promoting sodium and water excretion.
estrogen only
progesterone
human chorionic gonadotropin
relaxin only
Solution
The main function of the mammalian corpus luteum is to produce progesterone, which maintains the endometrium for potential pregnancy. NCERT XII chapter Chemical Coordination and Integration highlights this role, so option (b) is correct.
High level of FSH and LH stimulates the thickening of endometrium
High level of FSH and LH facilitate implantation of the embryo
High level of hCG stimulates the synthesis of estrogen and progesterone
High level of hCG stimulates the thicknening of endometrium
Solution
In a normal pregnant female, high levels of human chorionic gonadotropin (hCG) stimulate the corpus luteum to produce estrogen and progesterone, which maintain the endometrium. NCERT XII chapter Chemical Coordination and Integration describes this role of hCG, so option (c) is correct.
Hallucinogen
Depressant
Stimulant
Pain-killer
Solution
The plant shown is Cannabis sativa, which produces hallucinogens like THC. NCERT XII chapter Chemical Coordination and Integration discusses the classification of drugs, identifying Cannabis as a hallucinogen, so option (a) is correct.
Cortisone
Aldosterone
Insulin
Glucagon
Solution
Mineralocorticoid (Aldosterone) has no role in sugar metabolism. It helps in salt metabolism.
Antidiuretic hormone
Luteinizing hormone
Prolactin
Melanocyte stimulating hormone
Solution
Antidiuretic hormone is synthesized by the neurons of hypothalamus and stored in axon endings of posterior lobe of pituitary and released into the blood by posterior pituitary.
Parathormone - Calcitonin
Insulin - Glucagon
Aldosterone - Atrial Natriuretic Factor
Relaxin - Inhibin
Solution
Parathormone → Increases blood 𝐶𝑎+2 level Calcitonin → Decreases blood 𝐶𝑎+2 level Insulin → Decreases blood glucose level Glucagon → Increases blood glucose level Aldosterone → Increases B.P. ANF → Decreases B.P. Relaxin → Causes pelvic musculature relaxation www.vedantu.com 52 Inhibin → Inhibits FSH
Estrogen and progesterone
Estrogen and inhibin
Progesterone only
Progesterone and inhibin
Solution
GnRH pulse frequency in controlled by estrogen and progesterone both after puberty.
Inhibits the secretion of LH, FSH and Prolactin
Is produced by granulose cells in ovary and inhibits the secretion of FSH
Is produced by granulose cells in ovary and inhibits the secretion of LH
Is produced by nurse cells in testes and inhibits the secretion of LH
Solution
Inhibin is produced by granulosa cells in the ovary and inhibits the secretion of FSH – follicle stimulating hormone.
Melatonin and Serotonin
Thyroxine and Triiodothyronine
Estrogen and Progesterone
Cortisol and Cortisone
Solution
Amino acid tryptophan is the precursor for the synthesis of melatonin and serotonin. www.vedantu.com 65
Pineal gland
Corpus cardiacum
Corpus luteum
Corpus allatum
Solution
Corpus luteum is the temporary endocrine structure formed in the ovary after ovulation. It is responsible for the release of the hormones like progesterone, oestrogen etc.
Anterior pituitary gland and stimulates secretion of LH and oxytocin
Anterior pituitary gland and stimulates secretion of LH and FSH
Posterior pituitary gland and stimulates secretion of oxytocin and FSH
Posterior pituitary gland and stimulates secretion of LH and relaxin
Solution
Hypothalamus secretes GnRH which stimulates anterior pituitary gland for the secretion of gonadotropins (FSH and LH).
Estradiol
Ecdysone
Epinephrine
Estriol
Solution
Epinephrine is derived from the amino acid tyrosine. NCERT XII chapter Chemical Coordination and Integration classifies epinephrine as an amino acid-derived hormone, so option (c) is correct.
Estrogen and Parathyroid hormone
Progesterone and Aldosterone
Aldosterone and Prolactin
Parathyroid hormone and Prolactin
Solution
Estrogen and parathyroid hormone play significant roles in osteoporosis. Estrogen helps maintain bone density, while parathyroid hormone regulates calcium levels, affecting bone resorption. NCERT XII chapter Chemical Coordination and Integration discusses these hormonal roles in calcium metabolism and bone health, so option (a) is correct.
Phosphofructokinase
Aldolase
Hexokinase
Enolase
Solution
Ref. XI NCERT Chapter- 14, Page No. 229
(iii) (iv) (i) (ii)
(i) (iii) (ii) (iv)
(iii) (i) (ii) (iv)
(iii) (i) (iv) (ii)
Solution
Ref. XII NCERT Chapter- 06, Page No. 116
(iv) (iii) (i) (ii)
(iii) (ii) (i) (iv)
(iii) (i) (iv) (ii)
(ii) (i) (iv) (iii)
Solution
- Pituitary gland is associated with diabetes insipidus due to antidiuretic hormone (ADH) deficiency.
- Thyroid gland is linked to Grave’s disease, an autoimmune disorder causing hyperthyroidism.
- Adrenal gland is related to Addison’s disease, characterized by insufficient cortisol and aldosterone production.
- Pancreas is associated with diabetes mellitus, a condition of impaired insulin function.
Alpha cells of pancreas
The cells of rostral adenohypophysis
The cells of bone marrow
Juxtaglomerular cells of the kidney
Solution
Erythropoietin is produced by juxtaglomerular cells of the kidney. This hormone stimulates red blood cell production in the bone marrow, as described in NCERT XII chapter Chemical Coordination and Integration, so option (d) is correct.
(b) and (d) only
(b) and (c) only
(a), (c) and (d) only
(a) and (d) only
Solution
Mature insulin does not contain C-peptide, as it is cleaved during the processing of pro-insulin. Pro-insulin contains C-peptide, and the A-peptide and B-peptide of insulin are interconnected by disulphide bridges. Therefore, option (c) is correct.
Both ) A ( and ) R ( are correct and ) R ( is the correct explanation of ) A(
Both (A) and (R) are correct but (R) is not the correct explanation of (A)
)A ( is correct but ) R ( is not correct
(A) is not correct but (R) is correct
Solution
Option (3) is the correct answer as osteoporosis is due to decreased levels of oestrogen. Osteoporosis is an age-related disorder characterised by decreased bone mass hence, the chances of fractures increase.
The atrio-ventricular node (AVN) generates an action potential to stimulate atrial contraction
The tricuspid and the bicuspid valves open due to the pressure exerted by the simultaneous contraction of the atria
Blood moves freely from atrium to the ventricle during joint diastole.
Increased ventricular pressure causes closing of the semilunar valves.
Solution
Option ( 3) is the correct answer because during joint diastole, blood moves f reely from atrium to ventricle as atrioventricular valve remain open during joint diastole. Option ( 4) is incorrect because decrease in ventricular pressure, during ventricular diastole closes semilunar valves to produce ‘dub’ heart sound. Option (1) is incorrect because SA node generates action potential to stimulate atrial contraction. Option (2) is incorrect because bicuspid and tricuspid valves open due to pressure exerted by blood present in atria and decrease in pressure in ventricles during ventricular diastole.
)a (and )c (only
(b), (d) and (e) only
)a (and )e (only
(b) and (c) only
Solution
Option ( 2) is the correct answer because parathyroid hormone is a hypercalcemic hormone i.e , it increases the blood calcium levels. It also increases the absorption of calcium from digested food. Glucocorticoids regulate the carbohydrate metabolism. Option (3) is not the answer because parathyroid hormone stimulates the process of bone resorption. Option (1) and (4) are not the answers because reabsorption of Ca 2+ by renal tubules is a function of PTH.
Maintenance of water and electrolyte balance
Regulation of basal metabolic rate
Normal rhythm of sleep-wake cycle
Development of immune system
Solution
Thyroid hormone primarily regulates basal metabolic rate, maintenance of water and electrolyte balance, and the normal rhythm of the sleep-wake cycle. The development of the immune system is not directly controlled by thyroid hormone, so option (d) is correct.
A-IV, B-I, C-II, D-III
A-I, B-II, C-III, D-IV
A-II, B-III, C-IV, D-I
A-III, B-IV, C-I, D-II
Solution
Correct answer is option (1) A. GLUT-4 IV. Enables glucose transport into cells B. Insulin I. Hormone C. Trypsin II. Enzyme D. Collagen III. Intercellular ground substance
Cortisol
Testosterone
Progesterone
Glucagon
Solution
The correct answer is option (4) as glucagon is a proteinaceous hormone secreted from pancreas. Options (1), (2) and (3) are not correct as they are steroid in nature.
A-I, B-III, C-II, D-IV
A-IV, B-II, C-I, D-III
A-III, B-IV, C-II, D-I
A-III, B-IV, C-I, D-II
Solution
The correct answer is option no. (4) as (A) Exophthalmic goiter (III) Hyper secretion of thyroid hormone and characterized by protruding eye balls (B) Acromegaly (IV) Excessive secretion of growth hormone (C) Cushing’s syndrome (I) Excess secretion of cortisol, moon face and hyperglycaemia (D) Cretinism (II) Hypo-secretion of thyroid hormone and characterized by stunted growth
A-IV, B-II, C-III, D-I
A-II, B-IV, C-I, D-III
A-III, B-II, C-IV, D-I
A-IV, B-II, C-I, D-III
Solution
- Progesterone is produced by the corpus luteum.
- Relaxin is produced by the ovary.
- Melanocyte stimulating hormone is produced by the pars intermedia.
- Catecholamines are produced by the adrenal medulla.
A-II, B-I, C-III, D-IV
A-IV, B-III, C-II, D-I
A-I, B-III, C-IV, D-II
A-III, B-I, C-IV, D-II
Solution
- Heart produces Atrial natriuretic factor (ANF), which regulates blood pressure and volume.
- Kidney produces Erythropoietin (EPO), which stimulates red blood cell production.
- Gastro-intestinal tract produces Secretin, which stimulates the secretion of bicarbonate from the pancreas.
- Adrenal Cortex produces Aldosterone, which regulates sodium and potassium balance.
C and D only
B, C and D only
A, C and D only
D only
Solution
Adrenal medullary hormones, primarily epinephrine and norepinephrine, cause piloerection (C), increase the strength of heart contraction (D), and act as hyperglycemic hormones by promoting glycogenolysis (B). Pupillary constriction (A) is not a function of these hormones, so option (b) is correct.
Human body will elicit strong immune response
It will be digested in Gastro-Intestinal (GI) tract
Because of structural variation
Its bioavailability will be increased
Solution
Insulin can't be administered orally to diabetic patients as being the proteinaceous molecule, it will be digested in gastro-intestinal tract.
Luteinizing hormone (LH)
Anti-diuretic hormone (ADH)
Follicle-stimulating hormone (FSH)
Adrenocorticotropic hormone (ACTH)
Solution
Neurohypophysis i.e., posterior pituitary (Pars nervosa) stores and releases two hormones called oxytocin and vasopressin (Also called ADH i.e., antidiuretic hormone) which are actually synthesised by hypothalamus and are transported axonally to neurohypophysis. The pars distalis (anterior pituitary) produces follicle stimulating hormone (FSH), adrenocorticotropic hormone (ACTH) and luteinizing hormone (LH).
(1) A-IV, B-II, C-I, D-III
(2) A-IV, B-II, C-III, D-I
(3) A-II, B-IV, C-I, D-III
(4) A-III, B-II, C-IV, D-I
Solution
The correct answer is [A-IV, B-II, C-I, D-III]
• Progesterone – A steroidal hormone which is secreted by the corpus luteum
• Relaxin – A proteinaceous hormone which is secreted by the ovaries in the later stage of pregnancy
• Melanocyte stimulating hormone – A proteinaceous hormone released by the pars intermedia
• Catecholamines – An amino-acid derived hormone released from the adrenal medulla during emergency conditions
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